Renal Pathology Tutorial

Written by: J. Charles Jennette, MD
Produced by: F.W. Maddux, MD
[Renal Pathology Tutorial Home Page]
[Normal Histology] [Clinical Presentation] [Nephrotic Syndrome] [Minimal Change]
[Membranous] [FSGS] [Type I MPGN] [Type II MPGN]

Clinical Presentations of Glomerular Diseases

Clinical Manifestations of Glomerular Disease
  • asymptomatic proteinuria
  • nephrotic syndrome
    (proteinuria, hypoproteinemia, lyperlipidemia, edema)
  • asymptomatic hematuria
  • glomerulonephritis
    (hematuria, proteinuria, hypertension, renal failure)
  • acute glomerulonephritis
    (neprhitis with short term renal failure)
  • crescentic glomerulonephritis
    (nephritis with rapidly progressive renal failure)
  • chronic glomerulonephritis
    (chronic progression of renal failure)
  • End Stage Renal Disease
    (irreversible renal failure)

The list above represents a number of clinical presentations for glomerular diseases. The categories include those diseases that cause primarily proteinuric conditions, either asymptomatic proteinuria or nephrotic syndrome; and those that cause either asymptomatic hematuria or nephritic syndrome with hematuria, proteinuria, renal insufficiency and/or hypertension. Nephritis can manifest as an acute, sometimes self-limited process, as a more chronic process with indolent progression of disease, or as a rapidly progressive process, which manifests often times structurally with substantial crescent formation. Any of the glomerular diseases that progress to severe chronic injury can result in end stage renal disease.


[Renal Pathology Tutorial Home Page]
[Normal Histology] [Clinical Presentation] [Nephrotic Syndrome] [Minimal Change]
[Membranous] [FSGS] [Type I MPGN] [Type II MPGN]

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